TNFRSF1A

Across TCGA cell cohorts, TNFRSF1A RNA expression is significantly associated with the go_rna of many other GO terms, with 5,767 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TNFRSF1A-associated GO terms across cancer lineages are Regulation of cell-substrate junction assembly, Cellular response to environmental stimulus, and Positive regulation of cell junction assembly. Each is linked with TNFRSF1A in more than 11 cancer types. Because this analysis shows association rather than direction, both TNFRSF1A-to-partner and partner-to-TNFRSF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate junction assembly grouped by TNFRSF1A-low versus TNFRSF1A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF1A→partner) and Y-score (partner→TNFRSF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate junction assembly →	+0.148	+1.322	<.001	<.001	3	12
LUNG_SCLC	Cellular response to environmental stimulus →	+0.050	+2.340	<.001	<.001	3	12
BONE	Positive regulation of cell junction assembly →	+0.097	+1.359	.001	.003	3	12
CNS	Intracellular receptor signaling pathway →	+0.060	+1.399	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Establishment of epithelial cell apical/basal polarity →	+0.224	+1.204	<.001	.002	3	12
BONE	Regulation of focal adhesion assembly →	+0.148	+1.322	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,767 associations by consensus.

Regulation of cell-substrate junction assembly by TNFRSF1A expression — BONE

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