TNFRSF14-AS1

Across TCGA pan-cancer cohorts, TNFRSF14-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TNFRSF14-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TNFRSF14-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNFRSF14-AS1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, STAD, and LUSC are the cancer types where TNFRSF14-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFRSF14-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.855	<.001	11	view →
STAD	All	II,III,IV	+1.144	<.001	8	view →
LUSC	Female	All	−1.133	<.001	8	view →
LUAD	Male	II,III,IV	−0.877	<.001	8	view →
THCA	Male	III,IV	+0.597	.003	6	view →
LIHC	Female	All	+0.685	.002	4	view →
UCEC	All	All	−0.407	.009	4	view →
COAD	Female	All	−0.472	<.001	3	view →
BRCA	Female	II,III,IV	−0.176	.036	3	view →
CHOL	All	All	+1.354	.006	2	view →
PRAD	All	All	+0.271	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TNFRSF14-AS1–KIRC

Open the KIRC breakdown →