TNFRSF11A

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TNFRSF11A protein abundance is significantly associated with the RNA expression of many other genes, with 1,756 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible TNFRSF11A-associated genes across cancer lineages are SNORA15B-1, PTK2B, and LARGE2. Each is linked with TNFRSF11A in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF11A-to-partner and partner-to-TNFRSF11A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TNFRSF11A versus SNORA15B-1 in LSCC, with a Pearson correlation of -0.69.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF11A→partner) and Y-score (partner→TNFRSF11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCSNORA15B-1 →-1.180-1.199.001<.00132
CCRCCPTK2B →+0.579+0.646.005.00732
LUADLARGE2 →-1.703-1.228.007.00132
HNSCKIAA1671 →+1.666+0.903.004.00532
LUADMAP3K5-AS1 →+0.669+0.848<.001<.00132
LSCCANOS1 →+1.114+0.795.003.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,756 associations by consensus.

TNFRSF11A vs SNORA15B-1 — LSCC

Per-sample scatter of TNFRSF11A vs SNORA15B-1 in LSCC (Pearson r = -0.69).

Explore this scatter interactively →

Exploration