TNFRSF11A

Across TCGA pan-cancer cohorts, TNFRSF11A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TNFRSF11A data layer compared with 7 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TNFRSF11A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TNFRSF11A expression acts as an unfavorable survival marker, although some lineages such as COAD and SKCM show a favorable association.

COAD, UVM, and KICH are the cancer types where TNFRSF11A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.820	0.688	<.001	82	view →
UVM	OS	Quartile	All	0.377	0.744	<.001	76	view →
KICH	DFS	Tertile	II,III,IV	0.517	0.934	.009	27	view →
KIRC	DFS	Tertile	IV	0.183	0.482	.002	24	view →
SKCM	OS	Tertile	IV	0.736	0.133	.003	23	view →
ESCA	OS	Tertile	All	0.307	1.000	.005	23	view →
LIHC	OS	Quartile	All	0.411	0.688	<.001	22	view →
ACC	DFS	Tertile	All	0.797	0.436	.004	20	view →
LUSC	DFS	Tertile	All	0.825	0.680	.001	17	view →
HNSC	DFS	Tertile	All	0.785	0.626	.002	16	view →
BLCA	OS	Quartile	III,IV	0.437	0.778	.006	15	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TNFRSF11A–COAD (DFS)

Open the COAD breakdown →