TNFRSF11A

Across TCGA patient cohorts, TNFRSF11A mutation is significantly associated with the RNA expression of many other genes, with 966 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF11A-associated genes across cancer lineages are CLUHP11, RNU6-639P, and RNU7-190P. Each is linked with TNFRSF11A in more than 2 cancer types. Because this analysis shows association rather than direction, both TNFRSF11A-to-partner and partner-to-TNFRSF11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLUHP11 grouped by TNFRSF11A-low versus TNFRSF11A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF11A→partner) and Y-score (partner→TNFRSF11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CLUHP11 →	+0.111	+3.784	<.001	.002	3	3
LGG	RNU6-639P →	+0.364	+7.977	<.001	.007	3	3
HNSC	RNU7-190P →	+0.482	+7.954	<.001	.008	3	3
SKCM	RN7SKP286 →	+0.046	+4.640	<.001	.003	3	3
GBM	MIR5708 →	+0.601	+6.614	<.001	<.001	3	2
SKCM	LDHAP2 →	+0.659	+3.208	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 966 associations by consensus.

CLUHP11 by TNFRSF11A expression — SKCM

Explore this box plot interactively →