TNFRSF11A

Across TCGA patient cohorts, TNFRSF11A mutation is significantly associated with the immune_cell of many other genes, with 8 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible TNFRSF11A-associated genes across cancer lineages are iDC, Adipocytes, and Neutrophils. Each is linked with TNFRSF11A in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF11A-to-partner and partner-to-TNFRSF11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, iDC grouped by TNFRSF11A-low versus TNFRSF11A-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF11A→partner) and Y-score (partner→TNFRSF11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	iDC →	-0.185	-2.991	.049	.036	3	1
UCEC	Adipocytes →	+0.016	+1.770	.043	.022	3	1
UCEC	Neutrophils →	+0.010	+1.581	.013	.038	3	1
LUSC	CD8+ naive T-cells →	-0.028	-2.321	.018	.036	1	2
LUSC	Basophils →	+0.182	+3.459	.003	.005	1	2
UCEC	Class-switched memory B-cells →	-0.055	-2.700	.034	.006	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

iDC by TNFRSF11A expression — LUSC

Explore this box plot interactively →