TNFRSF11A

Across TCGA cell cohorts, TNFRSF11A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,297 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible TNFRSF11A-associated GO terms across cancer lineages are Positive regulation of icosanoid secretion, Multinuclear osteoclast differentiation, and Positive regulation of prostaglandin secretion. Each is linked with TNFRSF11A in more than 12 cancer types. Because this analysis shows association rather than direction, both TNFRSF11A-to-partner and partner-to-TNFRSF11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of icosanoid secretion grouped by TNFRSF11A-low versus TNFRSF11A-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF11A→partner) and Y-score (partner→TNFRSF11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of icosanoid secretion →	-0.257	-1.656	<.001	<.001	3	13
BONE	Multinuclear osteoclast differentiation →	-0.203	-1.020	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Positive regulation of prostaglandin secretion →	-0.258	-1.741	.001	.003	2	12
BLOOD_Myeloma	Regulation of prostaglandin secretion →	-0.239	-1.786	.002	.002	2	11
STOMACH	Positive regulation of potassium ion import across plasma membrane →	+0.271	+2.040	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Regulation of muscle hypertrophy →	+0.112	+1.189	.004	.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,297 associations by consensus.

Positive regulation of icosanoid secretion by TNFRSF11A expression — STOMACH

Explore this box plot interactively →