TNFRSF11A

Across TCGA cell cohorts, TNFRSF11A mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TNFRSF11A-associated genes across cancer lineages are OR8B2, LCN1, and PRM3. Each is linked with TNFRSF11A in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF11A-to-partner and partner-to-TNFRSF11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B2 grouped by TNFRSF11A-low versus TNFRSF11A-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF11A→partner) and Y-score (partner→TNFRSF11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR8B2 →	+0.034	+5.029	<.001	.006	3	1
BLOOD_Leukemia	LCN1 →	+0.030	+4.922	.002	.009	3	1
BLOOD_Leukemia	PRM3 →	+0.090	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	TMEM239 →	+0.086	+5.201	<.001	.006	3	1
BLOOD_Leukemia	SPATA31A7 →	+0.038	+5.539	<.001	.003	3	1
LUNG_NSCLC_LUAD	C1QC →	+0.022	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

OR8B2 by TNFRSF11A expression — LUNG_SCLC

Explore this box plot interactively →