TNFRSF10D

Across TCGA patient cohorts, TNFRSF10D mutation is significantly associated with the RNA expression of many other genes, with 2,279 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF10D-associated genes across cancer lineages are RPS14P5, MCAT, and MYH9. Each is linked with TNFRSF10D in more than 2 cancer types. Because this analysis shows association rather than direction, both TNFRSF10D-to-partner and partner-to-TNFRSF10D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS14P5 grouped by TNFRSF10D-low versus TNFRSF10D-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF10D→partner) and Y-score (partner→TNFRSF10D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPS14P5 →	+0.083	+2.381	<.001	.004	3	3
UCEC	MCAT →	+0.413	+2.815	.002	.001	3	2
UCEC	MYH9 →	+0.493	+2.638	.004	.005	3	2
UCEC	AUP1 →	+0.315	+2.617	<.001	<.001	3	2
UCEC	PLCD4 →	+0.348	+3.732	.001	<.001	3	2
UCEC	HECTD3 →	+0.388	+2.098	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,279 associations by consensus.

RPS14P5 by TNFRSF10D expression — SKCM

Explore this box plot interactively →