TNFRSF10D

Across TCGA pan-cancer cohorts, TNFRSF10D RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TNFRSF10D’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TNFRSF10D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNFRSF10D is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KIRC, KICH, and LUAD are the cancer types where TNFRSF10D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFRSF10D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.771	<.001	9	view →
KICH	All	All	−1.485	<.001	7	view →
LUAD	All	All	−0.707	<.001	7	view →
LUSC	Female	All	−1.800	<.001	6	view →
BRCA	All	III,IV	−1.753	<.001	6	view →
STAD	Male	All	+1.004	.006	4	view →
HNSC	All	All	+0.639	.010	4	view →
BLCA	All	All	−0.842	.012	3	view →
PRAD	All	All	−0.692	<.001	2	view →
CHOL	All	All	+1.098	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TNFRSF10D–KIRC

Open the KIRC breakdown →