TNFRSF10D

Across TCGA patient cohorts, TNFRSF10D mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF10D-associated genes across cancer lineages are eIF4E, EGFR_pY1173, and AMPK_alpha. Each is linked with TNFRSF10D in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF10D-to-partner and partner-to-TNFRSF10D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TNFRSF10D-low versus TNFRSF10D-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF10D→partner) and Y-score (partner→TNFRSF10D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.179	+2.321	.042	.035	3	2
SKCM	EGFR_pY1173 →	-0.092	-3.169	.048	.017	3	1
SKCM	AMPK_alpha →	+0.174	+3.000	.012	.034	3	1
UCEC	EGFR →	-0.187	-2.459	.004	.019	3	1
UCEC	A-Raf_pS299 →	-0.098	-2.321	.047	.034	3	1
UCEC	FoxM1 →	+0.215	+2.321	.044	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eIF4E by TNFRSF10D expression — SKCM

Explore this box plot interactively →