TNFRSF10D

Across TCGA cell cohorts, TNFRSF10D RNA expression is significantly associated with the go_rna of many other GO terms, with 4,039 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TNFRSF10D-associated GO terms across cancer lineages are Cell-substrate junction assembly, Cellular response to mechanical stimulus, and Regulation of ERK1 and ERK2 cascade. Each is linked with TNFRSF10D in more than 8 cancer types. Because this analysis shows association rather than direction, both TNFRSF10D-to-partner and partner-to-TNFRSF10D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell-substrate junction assembly grouped by TNFRSF10D-low versus TNFRSF10D-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF10D→partner) and Y-score (partner→TNFRSF10D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Cell-substrate junction assembly →	+0.162	+2.277	<.001	<.001	3	9
LUNG_SCLC	Cellular response to mechanical stimulus →	+0.100	+1.899	.001	.001	3	9
PANCREAS	Regulation of ERK1 and ERK2 cascade →	+0.071	+1.103	<.001	.004	2	9
LUNG_SCLC	Cellular response to external stimulus →	+0.099	+1.899	.001	.001	3	8
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate adhesion →	+0.111	+2.077	.001	.001	3	7
PANCREAS	ERK1 and ERK2 cascade →	+0.144	+0.940	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,039 associations by consensus.

Cell-substrate junction assembly by TNFRSF10D expression — BREAST

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