TNFRSF10D

Across TCGA cell cohorts, TNFRSF10D mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible TNFRSF10D-associated genes across cancer lineages are XAGE5 and DEFA3. Each is linked with TNFRSF10D in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF10D-to-partner and partner-to-TNFRSF10D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XAGE5 grouped by TNFRSF10D-low versus TNFRSF10D-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF10D→partner) and Y-score (partner→TNFRSF10D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	XAGE5 →	+0.255	+5.196	<.001	.005	3	1
SKIN	DEFA3 →	+0.140	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

XAGE5 by TNFRSF10D expression — OVARY

Explore this box plot interactively →