TNFRSF10C

Across TCGA pan-cancer cohorts, TNFRSF10C Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TNFRSF10C data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TNFRSF10C Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TNFRSF10C expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SKCM, UCEC, and PRAD are the cancer types where TNFRSF10C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.377	0.733	.013	10	view →
UCEC	DFS	Median	All	1.000	0.831	.032	8	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
BLCA	DFS	Median	All	0.239	0.627	.037	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TNFRSF10C–SKCM (DFS)

Open the SKCM breakdown →