TNFRSF10C

Across TCGA pan-cancer cohorts, TNFRSF10C mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TNFRSF10C data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TNFRSF10C mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TNFRSF10C expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

PDAC, GBM, and LUAD are the cancer types where TNFRSF10C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.424	0.993	.002	36	view →
GBM	DFS	Median	All	0.802	0.613	.030	5	view →
LUAD	OS	Tertile	III,IV	0.404	1.000	.042	2	view →
LSCC	DFS	Median	All	0.828	0.498	.042	2	view →
HNSC	OS	Median	All	1.000	0.907	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TNFRSF10C–PDAC (OS)

Open the PDAC breakdown →