TNFRSF10B

Across TCGA patient cohorts, TNFRSF10B protein abundance is significantly associated with the RNA expression of many other genes, with 5,679 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TNFRSF10B-associated genes across cancer lineages are TNFRSF10A, TTYH1, and AP3S1. Each is linked with TNFRSF10B in more than 2 cancer types. Because this analysis shows association rather than direction, both TNFRSF10B-to-partner and partner-to-TNFRSF10B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TNFRSF10B versus TNFRSF10A in LSCC, with a Pearson correlation of 0.70.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF10B→partner) and Y-score (partner→TNFRSF10B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TNFRSF10A →	+1.581	+0.875	.001	.002	3	3
GBM	TTYH1 →	-0.994	-0.505	.002	.001	3	3
HNSC	AP3S1 →	+0.554	+0.424	.004	.005	3	3
GBM	ZNF821 →	-0.568	-0.595	<.001	<.001	3	2
GBM	HSD17B1P1 →	-0.681	-0.549	<.001	<.001	3	2
GBM	TRMT13 →	-0.400	-0.359	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,679 associations by consensus.

TNFRSF10B vs TNFRSF10A — LSCC

Explore this scatter interactively →