TNFRSF10B

Across TCGA pan-cancer cohorts, TNFRSF10B RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TNFRSF10B data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher TNFRSF10B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TNFRSF10B expression acts as an unfavorable survival marker, although some lineages such as BRCA and ESCA show a favorable association.

MESO, ACC, and LGG are the cancer types where TNFRSF10B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.259	0.507	<.001	96	view →
ACC	DFS	Tertile	All	0.247	0.790	<.001	85	view →
LGG	DFS	Median	All	0.766	0.895	<.001	48	view →
KIRC	DFS	Quartile	II,III,IV	0.396	0.632	<.001	45	view →
LUSC	DFS	Median	All	0.316	0.462	<.001	36	view →
PAAD	DFS	Tertile	All	0.227	0.494	.003	34	view →
KICH	DFS	Tertile	III,IV	0.282	0.931	.007	29	view →
BRCA	OS	Quartile	II,III,IV	0.703	0.533	.006	24	view →
ESCA	OS	Median	All	0.637	0.468	.011	23	view →
BLCA	DFS	Quartile	All	0.275	0.646	.005	20	view →
LAML	DFS	Quartile	All	0.210	0.598	.005	20	view →
PCPG	DFS	Median	All	0.686	0.863	<.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TNFRSF10B–MESO (OS)

Open the MESO breakdown →