TNFRSF10B

Across TCGA patient cohorts, TNFRSF10B mutation is significantly associated with the RNA expression of many other genes, with 1,191 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF10B-associated genes across cancer lineages are SLC20A1P3, MCOLN1, and SNHG30. Each is linked with TNFRSF10B in more than 2 cancer types. Because this analysis shows association rather than direction, both TNFRSF10B-to-partner and partner-to-TNFRSF10B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC20A1P3 grouped by TNFRSF10B-low versus TNFRSF10B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF10B→partner) and Y-score (partner→TNFRSF10B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SLC20A1P3 →	+0.163	+7.502	<.001	<.001	3	3
UCEC	MCOLN1 →	+0.517	+2.415	<.001	.003	3	2
UCEC	SNHG30 →	+0.534	+3.708	.001	<.001	3	2
UCEC	NDUFA7 →	+0.438	+2.415	.004	.003	3	2
UCEC	RPL23AP82 →	+0.470	+3.467	<.001	.002	3	2
UCEC	LONP1 →	+0.544	+3.616	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,191 associations by consensus.

SLC20A1P3 by TNFRSF10B expression — COAD

Explore this box plot interactively →