TNFRSF10B

Across TCGA patient cohorts, TNFRSF10B mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFRSF10B-associated genes across cancer lineages are Cyclin-B1, 14-3-3_beta, and EGFR_pY1068. Each is linked with TNFRSF10B in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFRSF10B-to-partner and partner-to-TNFRSF10B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by TNFRSF10B-low versus TNFRSF10B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFRSF10B→partner) and Y-score (partner→TNFRSF10B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.583	+1.807	.011	.027	3	2
UCEC	14-3-3_beta →	-0.104	-3.143	.012	.018	3	1
UCEC	EGFR_pY1068 →	-0.330	-3.000	.001	.001	3	1
UCEC	A-Raf_pS299 →	-0.200	-3.459	<.001	.005	3	1
UCEC	ERK2 →	+0.263	+2.807	<.001	.003	3	1
UCEC	GAPDH →	+0.500	+1.807	.024	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Cyclin-B1 by TNFRSF10B expression — UCEC

Explore this box plot interactively →