TNFRSF10A

Across TCGA pan-cancer cohorts, TNFRSF10A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TNFRSF10A data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TNFRSF10A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TNFRSF10A expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where TNFRSF10A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.345	0.932	.008	10	view →
PDAC	OS	Tertile	All	0.479	1.000	.024	9	view →
CCRCC	DFS	Tertile	II,III,IV	0.247	1.000	.010	3	view →
LSCC	DFS	Tertile	All	1.000	0.489	.049	1	view →
HNSC	OS	Tertile	II,III,IV	0.883	0.620	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TNFRSF10A–LUAD (OS)

Open the LUAD breakdown →