TNFRSF10A-AS1

Across TCGA pan-cancer cohorts, TNFRSF10A-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TNFRSF10A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TNFRSF10A-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNFRSF10A-AS1 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KIRC, STAD, and KICH are the cancer types where TNFRSF10A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFRSF10A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.142	<.001	11	view →
STAD	Male	All	+1.224	<.001	9	view →
KICH	Female	II,III,IV	−1.680	<.001	8	view →
THCA	Female	III,IV	+0.898	<.001	7	view →
HNSC	All	All	+0.463	.004	6	view →
LUAD	Female	All	+0.661	<.001	5	view →
COAD	Male	All	+0.766	.004	4	view →
BRCA	Female	All	−0.274	.010	4	view →
CHOL	All	All	+1.513	<.001	3	view →
READ	All	III,IV	+1.625	.048	2	view →
BLCA	Male	III,IV	+1.277	.015	1	view →
ESCA	All	All	+1.080	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TNFRSF10A-AS1–KIRC

Open the KIRC breakdown →