TNFAIP8L2

Across TCGA pan-cancer cohorts, TNFAIP8L2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TNFAIP8L2 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TNFAIP8L2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TNFAIP8L2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where TNFAIP8L2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.718	0.472	.026	6	view →
PDAC	DFS	Tertile	III,IV	0.375	0.932	.031	5	view →
CCRCC	OS	Median	All	0.838	0.946	.038	2	view →
LSCC	OS	Quartile	III,IV	0.970	0.553	.047	2	view →
HNSC	DFS	Median	IV	0.783	0.582	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TNFAIP8L2–LUAD (DFS)

Open the LUAD breakdown →