TNFAIP8L2

Across TCGA pan-cancer cohorts, TNFAIP8L2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TNFAIP8L2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TNFAIP8L2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNFAIP8L2 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where TNFAIP8L2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFAIP8L2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+2.262	<.001	12	view →
THCA	Male	IV	+1.913	<.001	10	view →
KIRP	Male	All	+1.557	<.001	9	view →
COAD	All	All	−0.525	<.001	9	view →
LUSC	Male	II,III,IV	−1.931	<.001	8	view →
LUAD	Male	II,III,IV	−1.178	<.001	8	view →
STAD	All	II,III,IV	+0.993	.002	6	view →
BRCA	Female	All	+0.321	.002	4	view →
PAAD	All	All	−2.035	.021	2	view →
HNSC	Female	All	+0.735	.021	2	view →
UCEC	All	All	−0.483	.027	2	view →
ESCA	All	All	+0.918	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TNFAIP8L2–KIRC

Open the KIRC breakdown →