TNFAIP6

Across TCGA patient cohorts, TNFAIP6 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFAIP6-associated genes across cancer lineages are Rad50, PDCD4, and STAT3_pY705. Each is linked with TNFAIP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFAIP6-to-partner and partner-to-TNFAIP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by TNFAIP6-low versus TNFAIP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFAIP6→partner) and Y-score (partner→TNFAIP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.292	-3.000	.028	.036	3	1
UCEC	PDCD4 →	-0.620	-3.169	.016	.020	2	1
UCEC	STAT3_pY705 →	-0.560	-3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Rad50 by TNFAIP6 expression — UCEC

Explore this box plot interactively →