TNFAIP6

Across TCGA cell cohorts, TNFAIP6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,297 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TNFAIP6-associated GO terms across cancer lineages are Complement activation, classical pathway, Ovarian cumulus expansion, and Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. Each is linked with TNFAIP6 in more than 10 cancer types. Because this analysis shows association rather than direction, both TNFAIP6-to-partner and partner-to-TNFAIP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Complement activation, classical pathway grouped by TNFAIP6-low versus TNFAIP6-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFAIP6→partner) and Y-score (partner→TNFAIP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Complement activation, classical pathway →	+1.462	+1.502	<.001	.004	3	11
BONE	Ovarian cumulus expansion →	+1.952	+4.807	<.001	<.001	3	8
CNS	Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains →	+0.046	+1.350	.002	.004	3	8
SOFT_TISSUE	Immunoglobulin mediated immune response →	+0.087	+2.394	.002	.001	3	7
URINARY_TRACT	B cell mediated immunity →	+0.110	+2.491	<.001	.006	3	7
SOFT_TISSUE	Humoral immune response mediated by circulating immunoglobulin →	+0.317	+2.431	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,297 associations by consensus.

Complement activation, classical pathway by TNFAIP6 expression — BREAST

Explore this box plot interactively →