TNFAIP3

Across TCGA pan-cancer cohorts, TNFAIP3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TNFAIP3 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TNFAIP3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TNFAIP3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

PDAC, LUAD, and GBM are the cancer types where TNFAIP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	III,IV	0.379	0.977	.006	11	view →
LUAD	OS	Median	III,IV	0.268	0.837	.025	9	view →
GBM	OS	Median	All	0.266	0.459	.027	4	view →
UCEC	DFS	Quartile	III,IV	1.000	0.330	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TNFAIP3–PDAC (OS)

Open the PDAC breakdown →