TNFAIP1

Across TCGA patient cohorts, TNFAIP1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNFAIP1-associated genes across cancer lineages are TFRC, ATM, and eEF2. Each is linked with TNFAIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNFAIP1-to-partner and partner-to-TNFAIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by TNFAIP1-low versus TNFAIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNFAIP1→partner) and Y-score (partner→TNFAIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.621	+3.321	.007	.010	3	2
UCEC	ATM →	-0.570	-2.115	.003	.019	3	2
UCEC	eEF2 →	+0.444	+2.321	.004	.033	3	1
UCEC	eIF4G →	+0.289	+3.169	.033	.019	3	1
UCEC	ERK2 →	+0.202	+2.321	.016	.034	3	1
UCEC	FOXO3a_pS318_S321 →	-0.135	-2.807	.013	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

TFRC by TNFAIP1 expression — UCEC

Explore this box plot interactively →