TNFAIP1

Across TCGA pan-cancer cohorts, TNFAIP1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TNFAIP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TNFAIP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNFAIP1 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

HNSC, KICH, and COAD are the cancer types where TNFAIP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNFAIP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.289	<.001	12	view →
KICH	All	III,IV	−1.967	<.001	10	view →
COAD	Male	II,III,IV	+0.544	<.001	10	view →
LUAD	Female	All	−0.484	<.001	7	view →
LIHC	All	All	+0.445	<.001	7	view →
BLCA	All	All	+0.300	.008	6	view →
KIRP	All	IV	+1.122	.025	5	view →
STAD	All	II,III,IV	+0.815	<.001	4	view →
ESCA	All	All	+0.738	.012	4	view →
CHOL	Male	All	+1.586	<.001	3	view →
READ	Male	All	+0.780	.008	3	view →
KIRC	All	All	+0.242	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TNFAIP1–HNSC

Open the HNSC breakdown →