TNC

Across TCGA pan-cancer cohorts, TNC Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated TNC data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher TNC Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TNC expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

LUSC, UCEC, and OV are the cancer types where TNC Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.079	0.792	<.001	29	view →
UCEC	DFS	Median	All	0.780	0.625	.003	28	view →
OV	DFS	Median	All	0.255	0.542	.016	18	view →
ACC	OS	Median	All	0.273	0.802	.017	15	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LIHC	OS	Median	All	0.042	0.775	<.001	12	view →
LAML	DFS	Median	All	0.112	0.582	.010	6	view →
SCLC	OS	Median	III,IV	0.192	0.635	.019	6	view →
SARC	DFS	Median	All	0.154	0.543	.021	3	view →
SKCM	OS	Median	III,IV	0.380	0.735	.045	3	view →
LUAD	DFS	Median	All	0.786	0.326	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

TNC–LUSC (DFS)

Open the LUSC breakdown →