TMX4

Across TCGA pan-cancer cohorts, TMX4 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TMX4 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TMX4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMX4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LGG show a favorable association.

KIRC, OV, and BLCA are the cancer types where TMX4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.054	0.881	<.001	48	view →
OV	OS	Median	II,III,IV	0.308	0.691	.033	18	view →
BLCA	OS	Median	IV	0.217	0.607	.002	15	view →
CESC	DFS	Median	All	0.226	0.740	.017	12	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
UCEC	DFS	Median	III,IV	1.000	0.539	.042	10	view →
LGG	DFS	Median	All	1.000	0.379	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TMX4–KIRC (OS)

Open the KIRC breakdown →