TMX4

Across TCGA pan-cancer cohorts, TMX4 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TMX4’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where TMX4 RNA is repressed in tumor relative to normal tissue. In most cancer types TMX4 is over-expressed in tumor, although a few such as LUSC and BLCA show the opposite, repressed pattern.

LUSC, BLCA, and UCEC are the cancer types where TMX4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMX4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	III,IV	−1.513	<.001	8	view →
BLCA	Male	All	−1.337	<.001	8	view →
UCEC	All	All	−1.105	<.001	8	view →
LIHC	All	II,III,IV	+0.854	<.001	8	view →
BRCA	Female	All	−0.652	<.001	6	view →
THCA	Male	All	−0.495	<.001	6	view →
LUAD	All	III,IV	−0.715	.001	4	view →
KIRC	Male	III,IV	−0.334	.023	3	view →
CHOL	All	All	+0.874	.005	2	view →
PRAD	All	All	−0.357	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TMX4–LUSC

Open the LUSC breakdown →