TMX4

Across TCGA pan-cancer cohorts, TMX4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TMX4 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TMX4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMX4 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where TMX4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.617	0.815	.002	25	view →
HNSC	OS	Median	All	0.499	0.979	.020	8	view →
LUAD	DFS	Quartile	II,III,IV	0.698	0.909	.013	5	view →
GBM	DFS	Quartile	All	0.552	0.247	.001	5	view →
CCRCC	DFS	Median	III,IV	0.843	0.575	.018	4	view →
LSCC	DFS	Tertile	II,III,IV	0.498	1.000	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TMX4–PDAC (DFS)

Open the PDAC breakdown →