TMX4

Across TCGA patient cohorts, TMX4 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMX4-associated genes across cancer lineages are FOXO3a_pS318_S321, Rab25, and Src. Each is linked with TMX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMX4-to-partner and partner-to-TMX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by TMX4-low versus TMX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMX4→partner) and Y-score (partner→TMX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.145	-3.000	.045	.037	3	1
UCEC	Rab25 →	-0.518	-3.000	.006	.037	3	1
UCEC	Src →	-0.358	-3.000	.002	.037	3	1
UCEC	MEK1 →	+0.615	+3.000	.003	.036	2	1
UCEC	Cyclin-B1 →	+0.886	+3.000	.006	.037	1	2
UCEC	53BP1 →	+0.402	+3.000	.042	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

FOXO3a_pS318_S321 by TMX4 expression — UCEC

Explore this box plot interactively →