TMX4

Across TCGA cell cohorts, TMX4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible TMX4-associated genes across cancer lineages are GAGE10, PRR23C, and OR12D1. Each is linked with TMX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMX4-to-partner and partner-to-TMX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE10 grouped by TMX4-low versus TMX4-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMX4→partner) and Y-score (partner→TMX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GAGE10 →	+0.080	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	PRR23C →	+0.006	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	OR12D1 →	+0.012	+4.736	<.001	.009	3	1
LUNG_NSCLC_LUAD	CCDC172 →	+0.084	+4.544	<.001	.003	3	1
LARGE_INTESTINE	RBMY1B →	+0.006	+5.415	<.001	.004	3	1
LARGE_INTESTINE	RBMY1D →	+0.006	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GAGE10 by TMX4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →