TMX2-CTNND1

Across TCGA pan-cancer cohorts, TMX2-CTNND1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TMX2-CTNND1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TMX2-CTNND1 RNA is repressed in tumor relative to normal tissue. In most cancer types TMX2-CTNND1 is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

LUAD, BRCA, and READ are the cancer types where TMX2-CTNND1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMX2-CTNND1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	−0.141	<.001	7	view →
BRCA	All	II,III,IV	−0.140	<.001	6	view →
READ	Male	All	−0.166	.006	5	view →
COAD	All	All	−0.059	.008	5	view →
ESCA	Female	All	−0.106	<.001	3	view →
LUSC	Male	II,III,IV	−0.168	.011	2	view →
KICH	All	All	−0.122	.005	2	view →
PRAD	All	All	−0.087	.011	2	view →
KIRC	Female	All	+0.109	.013	1	view →
STAD	Male	All	−0.095	.049	1	view →
THCA	All	II,III,IV	−0.070	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TMX2-CTNND1–LUAD

Open the LUAD breakdown →