TMUB1

Across TCGA pan-cancer cohorts, TMUB1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TMUB1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TMUB1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TMUB1 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

CCRCC, COAD, and LSCC are the cancer types where TMUB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.623	1.000	.005	22	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.886	.020	18	view →
LSCC	OS	Median	II,III,IV	0.667	0.868	.026	6	view →
PDAC	OS	Quartile	All	0.974	0.724	.041	3	view →
HNSC	DFS	Tertile	IV	1.000	0.891	.040	2	view →
LUAD	DFS	Tertile	III,IV	0.993	0.625	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TMUB1–CCRCC (OS)

Open the CCRCC breakdown →