TMUB1

Across TCGA pan-cancer cohorts, TMUB1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TMUB1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMUB1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMUB1 is over-expressed in tumor.

HNSC, BLCA, and COAD are the cancer types where TMUB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMUB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.717	<.001	12	view →
BLCA	All	All	+0.933	<.001	11	view →
COAD	Female	II,III,IV	+0.554	<.001	11	view →
KIRP	All	IV	+1.490	<.001	9	view →
LUSC	Male	III,IV	+1.112	<.001	8	view →
LIHC	Female	All	+0.831	<.001	8	view →
LUAD	All	III,IV	+0.888	<.001	7	view →
UCEC	All	All	+0.871	<.001	6	view →
BRCA	All	III,IV	+0.650	<.001	6	view →
KIRC	All	III,IV	+0.311	.004	5	view →
STAD	All	II,III,IV	+0.602	.001	4	view →
CHOL	Male	All	+0.918	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TMUB1–HNSC

Open the HNSC breakdown →