TMUB1

Across TCGA patient cohorts, TMUB1 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible TMUB1-associated genes across cancer lineages are SPATA31D4, RN7SKP167, and RNA5SP337. Each is linked with TMUB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMUB1-to-partner and partner-to-TMUB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31D4 grouped by TMUB1-low versus TMUB1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMUB1→partner) and Y-score (partner→TMUB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SPATA31D4 →	+0.009	+7.954	<.001	.008	3	2
UCEC	RN7SKP167 →	+0.099	+4.132	.002	.009	3	2
BLCA	RNA5SP337 →	+0.333	+7.640	<.001	.009	3	2
LUAD	OR9G1 →	+0.077	+5.739	<.001	.001	3	1
LUAD	OR2T3 →	+0.041	+4.984	<.001	.005	3	1
LUAD	RNA5SP90 →	+0.613	+4.787	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

SPATA31D4 by TMUB1 expression — HNSC

Explore this box plot interactively →