TMTC1

Across TCGA patient cohorts, TMTC1 mutation is significantly associated with the RNA expression of many other genes, with 5,475 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMTC1-associated genes across cancer lineages are CDC20, WDR74, and VRK1. Each is linked with TMTC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMTC1-to-partner and partner-to-TMTC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDC20 grouped by TMTC1-low versus TMTC1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMTC1→partner) and Y-score (partner→TMTC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDC20 →	+0.890	+1.982	<.001	<.001	3	4
SKCM	WDR74 →	+0.494	+3.328	.004	.005	3	4
UCEC	VRK1 →	+0.435	+1.882	.004	.001	3	3
LUAD	RNASEH2A →	+0.527	+2.087	<.001	<.001	3	3
LUAD	RBM28 →	+0.323	+2.321	<.001	.005	3	3
LUAD	CCNJ →	+0.397	+1.700	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,475 associations by consensus.

CDC20 by TMTC1 expression — LUAD

Explore this box plot interactively →