Across TCGA patient cohorts, TMSB4X mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMSB4X-associated genes across cancer lineages are EGFR_pY1068, ERK2, and HSP70. Each is linked with TMSB4X in more than 1 cancer types. Because this analysis shows association rather than direction, both TMSB4X-to-partner and partner-to-TMSB4X results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMSB4X→partner) and Y-score (partner→TMSB4X) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.308	-3.000	.008	.036	3	1
UCEC	ERK2 →	+0.291	+3.321	.001	.010	3	1
UCEC	HSP70 →	-0.443	-3.449	.018	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.174	-3.000	.027	.036	3	1
UCEC	JNK2 →	+0.250	+3.700	.007	.001	3	1
UCEC	p70-S6K_pT389 →	-0.231	-3.160	.009	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

TMSB4X survival (RNA) · tumor vs normal (RNA) · all TMSB4X data types