Across TCGA pan-cancer cohorts, TMSB4X RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TMSB4X data layer compared with 4 for mutation status and 5 for mass-spec protein.
The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TMSB4X RNA is associated with better overall survival. In most high-consensus cancer types, elevated TMSB4X expression acts as an unfavorable survival marker, although some lineages such as SKCM and COAD show a favorable association.
SKCM, COAD, and UVM are the cancer types where TMSB4X RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.