TMSB15A

Across TCGA patient cohorts, TMSB15A mutation is significantly associated with the RNA expression of many other genes, with 262 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMSB15A-associated genes across cancer lineages are GUF1, BUB1B, and HMHB1. Each is linked with TMSB15A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMSB15A-to-partner and partner-to-TMSB15A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUF1 grouped by TMSB15A-low versus TMSB15A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMSB15A→partner) and Y-score (partner→TMSB15A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GUF1 →	+0.699	+3.212	<.001	.009	3	1
UCEC	BUB1B →	+0.989	+3.332	.003	.005	3	1
UCEC	HMHB1 →	+0.328	+2.959	<.001	.001	3	1
UCEC	H2AZ1 →	+0.749	+3.354	.005	.005	3	1
UCEC	METTL2B →	+0.553	+3.370	<.001	.004	3	1
UCEC	DNAJC7 →	+0.590	+3.210	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 262 associations by consensus.

GUF1 by TMSB15A expression — UCEC

Explore this box plot interactively →