TMSB15A

Across TCGA pan-cancer cohorts, TMSB15A RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TMSB15A data layer compared with 4 for mutation status.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher TMSB15A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TMSB15A expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

STAD, ACC, and KICH are the cancer types where TMSB15A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	II,III,IV	0.479	0.653	<.001	120	view →
ACC	OS	Median	All	0.423	0.778	<.001	116	view →
KICH	OS	Median	All	0.753	1.000	.002	93	view →
BRCA	DFS	Median	III,IV	0.368	0.620	<.001	72	view →
KIRC	DFS	Median	All	0.876	0.712	<.001	47	view →
UCS	DFS	Tertile	III,IV	0.568	0.093	.002	46	view →
KIRP	DFS	Quartile	II,III,IV	0.343	0.805	<.001	41	view →
SARC	DFS	Tertile	All	0.291	0.671	<.001	27	view →
CHOL	OS	Quartile	II,III,IV	0.996	0.135	.004	20	view →
OV	OS	Quartile	IV	0.632	0.244	.001	14	view →
THYM	OS	Median	All	1.000	0.660	.006	14	view →
ESCA	DFS	Quartile	All	1.000	0.191	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TMSB15A–STAD (OS)

Open the STAD breakdown →