TMSB15A

Across TCGA patient cohorts, TMSB15A mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMSB15A-associated genes across cancer lineages are ACC1, IGFBP2, and STAT3_pY705. Each is linked with TMSB15A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMSB15A-to-partner and partner-to-TMSB15A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by TMSB15A-low versus TMSB15A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMSB15A→partner) and Y-score (partner→TMSB15A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.541	+3.000	.010	.037	3	1
UCEC	IGFBP2 →	-0.787	-3.000	.036	.037	3	1
UCEC	STAT3_pY705 →	-0.442	-3.000	.003	.037	3	1
UCEC	Tuberin →	+0.501	+2.817	.001	.036	3	1
UCEC	Bid →	-0.143	-3.000	.039	.036	3	1
UCEC	c-Met_pY1235 →	+0.133	+3.000	.001	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ACC1 by TMSB15A expression — UCEC

Explore this box plot interactively →