TMSB10

Across TCGA pan-cancer cohorts, TMSB10 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TMSB10 data layer compared with 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TMSB10 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMSB10 expression acts as an unfavorable survival marker, although some lineages such as SKCM and ESCA show a favorable association.

ACC, LUAD, and LGG are the cancer types where TMSB10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.272	0.637	<.001	118	view →
LUAD	OS	Median	II,III,IV	0.191	0.323	<.001	74	view →
LGG	OS	Median	All	0.356	0.558	<.001	54	view →
LIHC	OS	Median	III,IV	0.222	0.450	<.001	51	view →
HNSC	DFS	Tertile	All	0.615	0.773	.002	51	view →
UCS	OS	Median	III,IV	0.419	0.748	.009	48	view →
STAD	DFS	Quartile	III,IV	0.379	0.720	.009	42	view →
MESO	OS	Tertile	All	0.189	0.451	.003	37	view →
BRCA	DFS	Tertile	III,IV	0.776	0.927	.004	31	view →
SKCM	OS	Median	II,III,IV	0.401	0.255	.003	29	view →
KIRC	DFS	Quartile	All	0.414	0.738	.001	28	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TMSB10–ACC (DFS)

Open the ACC breakdown →