TMPRSS9

Across TCGA patient cohorts, TMPRSS9 mutation is significantly associated with the RNA expression of many other genes, with 5,012 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS9-associated genes across cancer lineages are HSPD1P1, DNA2, and SEH1L. Each is linked with TMPRSS9 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMPRSS9-to-partner and partner-to-TMPRSS9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPD1P1 grouped by TMPRSS9-low versus TMPRSS9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS9→partner) and Y-score (partner→TMPRSS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPD1P1 →	+0.437	+2.938	<.001	<.001	3	4
UCEC	DNA2 →	+0.552	+3.711	.001	<.001	3	4
UCEC	SEH1L →	+0.482	+2.255	<.001	<.001	3	4
UCEC	LMNB1 →	+0.671	+2.595	.001	.005	3	3
UCEC	SET →	+0.532	+2.212	<.001	<.001	3	3
COAD	ATF1 →	+0.549	+3.486	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,012 associations by consensus.

HSPD1P1 by TMPRSS9 expression — UCEC

Explore this box plot interactively →