TMPRSS5

Across TCGA patient cohorts, TMPRSS5 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,435 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMPRSS5-associated proteins across cancer lineages are DLAT, NFIX, and SNAP23_S161. Each is linked with TMPRSS5 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMPRSS5-to-partner and partner-to-TMPRSS5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMPRSS5 versus DLAT in GBM, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS5→partner) and Y-score (partner→TMPRSS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DLAT →	+0.378	+0.809	<.001	<.001	3	4
BRCA	NFIX →	+0.452	+0.786	<.001	<.001	3	4
LSCC	SNAP23_S161 →	-0.395	-0.533	.006	.005	3	3
HNSC	ATP10D_S613 →	-0.631	-0.791	<.001	<.001	3	3
LSCC	FAM76B_S193 →	+0.506	+0.784	<.001	<.001	3	3
PDAC	GNB1 →	+0.460	+0.429	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,435 associations by consensus.

TMPRSS5 vs DLAT — GBM

Explore this scatter interactively →