TMPRSS5

Across TCGA cell cohorts, TMPRSS5 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMPRSS5-associated genes across cancer lineages are ZSCAN1, TBATA, and GOT1L1. Each is linked with TMPRSS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS5-to-partner and partner-to-TMPRSS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZSCAN1 grouped by TMPRSS5-low versus TMPRSS5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS5→partner) and Y-score (partner→TMPRSS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZSCAN1 →	+0.044	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TBATA →	+0.072	+3.196	<.001	.007	3	1
LARGE_INTESTINE	GOT1L1 →	+0.023	+4.022	<.001	.006	3	1
LARGE_INTESTINE	SPRR4 →	+0.080	+3.345	<.001	.007	3	1
LARGE_INTESTINE	FAM205C →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR2A25 →	+0.019	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ZSCAN1 by TMPRSS5 expression — LARGE_INTESTINE

Explore this box plot interactively →