Across TCGA patient cohorts, TMPRSS11F mutation is significantly associated with the RNA expression of many other genes, with 4,677 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS11F-associated genes across cancer lineages are ACYP1, ZNHIT3, and ZWINT. Each is linked with TMPRSS11F in more than 4 cancer types. Because this analysis shows association rather than direction, both TMPRSS11F-to-partner and partner-to-TMPRSS11F results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11F→partner) and Y-score (partner→TMPRSS11F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ACYP1 →	+0.568	+3.954	.001	<.001	3	5
UCEC	ZNHIT3 →	+0.394	+2.150	<.001	<.001	3	4
LUAD	ZWINT →	+0.863	+3.918	.001	<.001	3	4
LUAD	GINS2 →	+0.962	+2.807	<.001	.003	3	4
LUAD	CCNB1 →	+0.938	+3.486	.001	.002	3	4
UCEC	CPAMD8 →	-0.791	-1.828	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,677 associations by consensus.

Exploration

TMPRSS11F survival (RNA) · tumor vs normal (RNA) · all TMPRSS11F data types