Across TCGA patient cohorts, TMPRSS11F mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS11F-associated genes across cancer lineages are Cyclin-B1, 4E-BP1, and FASN. Each is linked with TMPRSS11F in more than 3 cancer types. Because this analysis shows association rather than direction, both TMPRSS11F-to-partner and partner-to-TMPRSS11F results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11F→partner) and Y-score (partner→TMPRSS11F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.542	+3.906	<.001	<.001	3	4
UCEC	4E-BP1 →	+0.274	+1.784	<.001	<.001	3	3
STAD	FASN →	+0.432	+2.321	.021	.034	3	2
STAD	TFRC →	+0.700	+2.321	.012	.034	2	3
LUSC	ACC1 →	+0.539	+3.179	.010	.010	3	2
LUSC	4E-BP1_pS65 →	+0.395	+3.179	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Exploration

TMPRSS11F survival (RNA) · tumor vs normal (RNA) · all TMPRSS11F data types